Preparation of baicalin nasal gel and its permeation through nasal mucosa / 中草药

ABSTRACT

Objective: To prepare the nasal gel of baicalin and to evaluate its permeation in vitro. Methods: The orthogonal design was carried out using Cabopol-936 as gel matrix, glycerine as solubilizer, and triethanolamine as pH value and viscosity adjuster. The permeating rate of baicalin from nasal gel was determined through pig nasal mucosa in vitro by transdermal diffusion method. Results: The optimum nasal gel was made by 0.5% Carbomer-936, 30% glycerine, and 2% baicalin, with pH value 6.85-7.00, and the average viscosity was 1850-2350 Pa·s. The permeation of baicalin through nasal mucosa was fitted with first-order kinetics, the regression equation was Y=0.2806 X+0.5643, r=0.997, and the permeating rate was 0.2806 μg/(mm2·h). Conclusion: The preparation of baicalin nasal gel is simple. Baicalin is almost permeated through nasal mucosa by simple diffusion.