Inhibition of isobavachalcone on IL-4 production and its mechanism / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1299-1304, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-855339
ABSTRACT
Objective:
To screen the small molecular compounds with anti-asthma activity from Psoralea corylifolia monomor and explain its regulation mechanism.Methods:
Based on the effect of IL-4 in pathological features of masthma, a high throughput screening system was designed by using 4get mice and flow cytometry to inhibit IL-4 production so as to anti-asthma.Results:
Compared with DMSO group, isobavachalcone showed high ability of inhibiting IL-4 production in Th2 cells (P < 0.001), down-regulating GATA-3 expression (P < 0.01), and decreasing the level of STAT6 phosphorylation (P < 0.01).Conclusion:
Isobavachalcone could inhibit the IL-4 production through down-regulating the GATA-3 expression by controling the level of STAT6 phosphorylation. Isobavachalcone is a potential drug for the treatment of asthma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2013
Type:
Article
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