Effect of Elaeagnus pungens leaves on contraction of isolated guinea pig tracheal smooth muscle / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1305-1308, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-855340
ABSTRACT
Objective:
To investigate the effect of n-butanol fraction from Elaeagnus pungens leaves (BFEP) on the contraction of isolated guinea pig tracheal smooth muscle under the basal tonus or spasmogens.Methods:
Guinea pig tracheal smooth muscle spiral strips were isolated. Under the normal state or the condition treated with acetylchohne (Ach), histamine (Hist), or KCl, Ca2+ release in cells without calcium, and extracellular Ca2+ influx at the high concentration of Ca2+, the effect of BFEP on the tension of isolated trachea was observed.Results:
BFEP relaxed the tracheal strip significantly in the concentration-dependent manner under the basal tonus. The tested drug produced an unparallel rightward shift of the cumulative concentration-response curve of Hist or Ach. The contraction induced by high K+ and extracellular Ca2+ influx was inhibited.Conclusion:
BFEP could inhibit the contraction of isolated guinea pig tracheal smooth muscle under the basal tonus or spasmogens.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2013
Type:
Article
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