Chemical constituents from twigs and leaves of Ervatamia hainanensis / 中草药

ABSTRACT

Objective: To investigate the chemical constituents in the twigs and leaves of Ervatamia hainanensis. Methods: The chemical constituents were isolated by silica gel, Sephadex LH-20, and ODS columns, as well as RP-HPLC chromatography. Their structures were identified on the basis of physicochemical properties and spectral analyses. Results: Thirteen compounds were isolated and idenified as coronaridine (1), 19-heyneanine (2), 19-epi-heyneanine (3), coronaridine hydroxyindolenine (4), vobasine (5), ursolic acid (6), asiatic acid (7), 8α-hydroxypinoresinol (8), (+)-syringarosinol (9), ervatamisin [(-)-(7R, 7'R, 7″R, 8S, 8'S, 8″S)-4', 4″-dihydroxy-3, 3', 3″, 5-tetramethoxy-7, 9', 7', 9-diepoxy-4, 8″-oxy-8, 8'-sesquineolignan-7″, 9″-diol, 10], toddalolactone (11), threo-2, 3-bis-(4-hydroxy-3-methoxypheyl)-3-methoxy-propanol (12), and β-sitosterol (13). Conclusion: Compounds 6-8 and 10-12 are isolated from the plants of Ervatamia (A. DC.) Stapf for the first time, and compound 9 is firstly reported from E. hainanensis.