Effect of nano-CaCO3 modified with by stearic acid on spray drying powder of angelica / 中草药

ABSTRACT

Objective: To prepare hydrophobic nano-CaCO3 modified by stearic acid and to study its application in spray drying power of angelica. Methods: The stearic acid was used on the surface characteristic of nano-CaCO3, and the modified and unmodified nano-CaCO3 was analyzed and investigated by means of oil absorption value, activation index (H), angle of repose, transmission electron microscopy (TEM), and Fourier transforms infrared (FTIR). The effect of modified nano-CaCO3 on moisture absorption, fluidity, and in vitro dissolution of ferulic acid in spray drying power of angelica were investigated, comparing with silicon dioxide and unmodified nano-CaCO3. Results: FTIR analysis showed that stearic acid has attached to CaCO3 surface. Powder flow and powder moisture absorption were improved in modified nano-CaCO3 and the effect was better than silica dioxide and unmodified nano-CaCO3. The in vitro dissolution of ferulic acid was not affected. Conclusion: The application of the nano-CaCO3 modified by stearic acid in the spray drying power of Chinese materia medica deserves to be studied further.