Preparation technology of chrysophanol freeze-dried liposomes / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 960-964, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-855381
ABSTRACT
Objective:
To establish a method for the preparation of chrysophanol freeze-dried liposomes.Methods:
The liposome suspension was prepared by film-ultrasonic dispersion method. The entrapment efficiency (EE) was determined by low-speed centrifugation and the influences of pre-freezing time, drying time, and type, dosage, and adding methods of the protective agents on EE of the freeze-dried liposome were studied.Results:
The pre-freezing time was 24 h, the drying time was 24 h, mannitol-sucrose (mass ratio 11) as protective agent was externally added to get uniform particle with good redissolution and the EE was (61.30 ± 2.2)%.Conclusion:
The liposome prepared by film-ultrasonic dispersion method is protected by mannitol-sucrose to get uniform particle size with the excellent redissolution and high EE.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2013
Type:
Article
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