Anti-inflammatory activity of Weichang'an Pill / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1017-1021, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-855392
ABSTRACT
Objective:
To study the active constituents in the methanol extract of Weichang'an Pill (MEWP) and their anti-inflammatory activity.Methods:
The HPLC method was used to anylyze the constituents in MEWP. The anti-inflammatory effects of MEWP were observed on the acute anti-inflammatory models of xylene-induced ear edema, carrageenan-induced paw edema, and acetic acid-induced vascular permeability; Meanwhile the chronic anti-inflammatory model of granuloma was induced by cotton pellet implantation.Results:
Twelve active constituents in MEWP were analyzed, including costunolide and dehydro-α-curcumene from Aucklandiae Radix; naringin, hesperedin, and neohesperedin from Aurantii Fructus; magnolol and honokiol from Magnoliae Officinalis Cortex; aloe-emodin, rhein, emodin, chrysophanol, and physcion from Rhei. Radix et Rhizoma. At the dose of 800 mg/kg, the MEWP showed the inhibitory rate of 39.46% on the ear edema and 35.37% on the increasing of capillary permeability induced by acetic acid in mice. It could decrease the paw edema caused by carrageenan after 1 h and inhibit the granuloma induced by cotton pellet implantation.Conclusion:
The MEWP could antagonize the reaction of inflammation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS