Pharmacodynamic effects of Persicae Semen extract on blood circulation disorder of rats induced by different symtoms / 中草药

ABSTRACT

Objective: To study the different pharmacodynamic effects of Persicae Semen extract (PSE) on the blood circulation disorder of rats induced by cold congeal and blood stasis syndrome (cold syndrome, CS), and heat congeal and blood stasis syndrome (heat syndrome, HS). Methods: Eighty rats were randomly divided into eight groups including normal control group of CS, model group of CS, PSE (8 g/kg) group of CS, Chanxiong Rhizoma (8 g/kg) group of CS, normal control group of HS, model group of HS, PSE (8 g/kg) group of HS, and Salviae Miltiorrhizae Radix (14 g/kg) group of HS. The two rat models were established by freezing and injection of carrageenan solution. The rats in each group were ig administered once daily for 7 d. The blood flow velocity (Fve) and blood viscosity (Vis) were detected; The organs (such as heart, lung, liver, kidney, and spleen) were taken and observed by histopathological analysis; The diameters of tiny blood vessels were measured by pathology image analysis software, and the thrombosis and tissue injury were observed. Results: PSE increased Fve but decreased Vis in CS and HS rats (P < 0.05), made the small artery in CS rats systolic, while that in HS rats diastolic (P < 0.05). The organ injury severity score indicated PSE could attenuate the injury of many organs (such as heart, lung, liver, and kidney) in CS rats, but only attenuated the injury of kidney in HS rats (P < 0.05). Conclusion: PSE could improve the blood circulation disorder induced by CS and HS. The different effects of PSE on the two kinds of syndromes include the regulation of the diastolic and systolic states of rat small artery and the different protection of rat organs.