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Preparation technology of matrine self-microemulsifying drugs / 中草药
Chinese Traditional and Herbal Drugs ; (24): 414-419, 2013.
Article in Chinese | WPRIM | ID: wpr-855427
ABSTRACT

Objective:

To develop the matrine self-microemulsifying drug delivery system (SMEDDS) and evaluate its quality.

Methods:

The solubility test and pseudoternary phase diagram were utilized to select proper matrine microemulsions prescription. On this basis, matrine-SMEDDS was formulated and HPLC method was used to determine the drug content in matrine-SMEDDS; The appearance, morphology, particle size, particle size distribution, Zeta potential, drug loading, and stability of matrine in the liposome were studied.

Results:

The best prescription of matrine-SMEDDS was matrine-oleic-ethyloleate-EL-40-isopropanol (0.50.150.150.350.35). The selected matrine-SMEDDS was transparent liquid with good liquidity and stability and could form O/W type microemulsion with water, with an average particle size of (68.00 ± 0.07) nm (n = 3). The average drug loading was 42.689 mg/mL (n = 3).

Conclusion:

The preparation technology is simple and stable, and provides a strong foundation for research of matrine-SMEDDS.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2013 Type: Article