Preparation technology of matrine self-microemulsifying drugs / 中草药

ABSTRACT

Objective: To develop the matrine self-microemulsifying drug delivery system (SMEDDS) and evaluate its quality. Methods: The solubility test and pseudoternary phase diagram were utilized to select proper matrine microemulsions prescription. On this basis, matrine-SMEDDS was formulated and HPLC method was used to determine the drug content in matrine-SMEDDS; The appearance, morphology, particle size, particle size distribution, Zeta potential, drug loading, and stability of matrine in the liposome were studied. Results: The best prescription of matrine-SMEDDS was matrine-oleic-ethyloleate-EL-40-isopropanol (0.50.150.150.350.35). The selected matrine-SMEDDS was transparent liquid with good liquidity and stability and could form O/W type microemulsion with water, with an average particle size of (68.00 ± 0.07) nm (n = 3). The average drug loading was 42.689 mg/mL (n = 3). Conclusion: The preparation technology is simple and stable, and provides a strong foundation for research of matrine-SMEDDS.