Studies on tanshinone IIA solid dispersion based on chitosan / 中草药

ABSTRACT

Objective: To prepare and characterize the solid dispersion of tanshinone IIA (Tan IIA) using chitosan (CS) and compare the dissolution of solid dispersion using CS with different molecular weight (MW). Methods: Tan IIA solid dispersion was prepared by the solvent method with CS as the carrier. The physical characteristics and in vitro dissolution of solid dispersion prepared by different MW of CS and different proportions of drug and carrier were further evaluated. Results: The ideal Tan IIA solid dispersion was prepared under the condition as follows: the weight ratio of Tan IIA-CS (MW 3 000-5 000) was 1:9. The in vitro dissolution of Tan IIA solid dispersion reached up to 90% at 60 min. The differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) demonstrated that Tan IIA existed as amorphous state in carriers. Conclusion: The results indicate that in vitro dissolution of Tan IIA is improved greatly by the solid dispersion with CS as the carrier. As a new type of solid dispersion carrier of Tan IIA, CS has its practical value.