Anti-aging mechanism of polysaccharide from rhizomorph of Armillaria mellea in Caenorhabditis elegans / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 449-453, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-855432
ABSTRACT
Objective:
To explore the anti-aging mechanism of polysaccharide from rhizomorph of Armillaria mellea (AMP) in Caenorhabditis elegans.Methods:
With C. elegans as living model, the life span and the average number of offsprings were determined under normal culture conditions; The survival rate under oxidative stress and the expression of heat shock protein-16.2 (HSP-16.2) and superoxide dismutase-3 (SOD-3) were determined.Results:
Under the normal culture conditions, the life span of C. elegans was significantly extended by AMP-1 and AMP-2 without the damage of the reproductive capacity; The expression of HSP-16.2 and SOD-3 was increased in C. elegans under the oxidative stress.Conclusion:
The possible mechanism of AMP for anti-aging of C. elegans may be caused by increasing of the capacity of stress resistance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2013
Type:
Article
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