Chemical constituents of Aconiti Lateralis Radix Praeparata / 中草药

ABSTRACT

Objective: To investigate the chemical constituents of Aconiti Lateralis Radix Praeparata. Methods: The constituents were isolated by silica gel, neutral alumina, Sephadex LH-20 gel, and medium-pressure MCI columns, and their structures were identified by chemical properties and spectroscopic analyses. Results: Eighteen compounds were isolated and their structures were elucidated as mesaconitine (1), aconitine (2), hypaconitine (3), 14-benzoylhypaconitine (4), 14-benzoylmesacontine (5), 14-benzoyaconitine (6), chasmanine (7), talatisamine (8), neoline (9), karakoline (10), fuziline (11), songorine (12), isotalatizidine (13), senbusine B (14), 16β-hydroxycardiopetaline (15), columbianine (16), benzoic acid (17), and 6-hydroxymethyl-3-pyridinol (18). Conclusion: Compounds 15-18 are obtained from this plant for the first time.