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Sustained-release solid dispersion of tripterin carried by colloidal silia dioxide / 中草药
Chinese Traditional and Herbal Drugs ; (24): 692-695, 2013.
Article in Chinese | WPRIM | ID: wpr-855446
ABSTRACT

Objective:

To prepare the sustained-release solid dispersion of tripterin (SRSDT) with the intention of improving drug dissolution, meanwhile, the drug release was slowed down so as to make the toxicity diminished.

Methods:

SRSDT was prepared by the solvent method with colloidal silica dioxide (CSD) as carrier. The physical characteristics and in vitro release rate were further evaluated.

Results:

The ideal SRSDT was prepared by mixing tripterin and colloidal silica dioxide with the weight ratio of 112; The release rate of drug could keep moderate and controllable. In vitro cumulative release of SRSDT was up to more than 90% after 8 h. The results of differential scanning calorimetry, scanning electron microscopy, and X-ray powder diffraction could prove that the tripterin existed as amorphous form in the carrier.

Conclusion:

The SRSDT carried by CSD could control the release rate of drug and keep moderate and controllable, and the preparation process is simple, which has potential applications.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2013 Type: Article