Preparation and in vitro drug release properties of salidroside-chitosan nanoparticles / 中草药

ABSTRACT

Objective: To prepare salidroside-chitosan nanoparticles (SA-CS-NPs) and to evaluate the properties of in vitro drug release. Methods: SA-CS-NPs were firstly prepared by solvent diffusion-ionic crosslinking method. The particle size and polydispersity of SA-CS-NPs were determined and the morphology of nanoparticles was evaluated. The properties of encapsulation efficiency (EE), load efficiency (LE), and in vitro release of SA-CS-NPs were also evaluated using UPLC method. Results: The nanoparticles were successfully prepared with the spherical shape or para-spherical shape. The mean particle size was (247.5 ± 23.8) nm with the polydispersity index (PDI) of 0.265 ± 0.071, and the Zeta potential was (23.4 ± 2.7) mV (n = 3). The EE was (70.15 ± 1.60)% and the LE was (14.03 ± 0.32)% (n = 3). The cumulative release rate of SA-CS-NPs within 24 h was over 85%. Conclusion: SA-CS-NPs prepared by solvent diffusion-ionic crosslinking method show appropriate particle size and EE, and could exhibit sustained release properties in vitro.