Chemical constituents of Leucas ciliata / 中草药

ABSTRACT

Objective To study the chemical constituents from Leucas ciliata. Methods Silica gel, RP-18, and Sephadex LH-2O column chromatography techniques were used for separation and purification of the compounds and extensive spectral analysis spectrum were employed for structural elucidation. Results Twelve compounds were isolated from ethanol extract of L. ciliata and identified as tricin (1), crisilineol (2), sitosterol-3-O-glucoside (3), stigmast-5-ene-11-ol- 3-O-β-glucoside (4), 5, 7-dimethoxy-2-methyl-4-chromanone (5), 3', 5', 5, 7-tetramethoxy-4'-O-β-glucoside flavone (6), 5-hydroxy-3', 4'-dimethoxy-7-O-β-glucoside flavone (7), acteoside (8), 3, 4-dihydroxy-β-phenylethoxy-O-ααrabinopyranosyl-(l""- →2")α-Z,-rhamnopyranosyl-(r"-→3") -4"-O-caffeoylβ-D-glucopyranoside (9), 3-hydroxy-4-methoxy-β- phenylethoxy-Oα-Lαrabinopyranosyl-(l""-→6") α-L-rhamnopyranosyl-(r"-→3")4"-O-caffeoyl-β-D- glucopyranoside (10), leucasin A (11A), and leucasin B (11B). Conclusion Compounds 11A and 11B are epimers and new compounds, and the other ten compounds are obtained from the plants of Leucas R. Br. for the first time.