Synthesis of diosgenin derivatives and their antithrombotic activity (II) / 中草药

ABSTRACT

Objective: To search antithrombotic substances from diosgenin derivatives by structure modification. Methods: The target compounds were synthesized by esterification reaction with diosgenin as the leading compound. Antithrombotic activity of these compounds was examined using the thrombogenesis model of arterio-veinous bypass in rats. Results: Nine compounds were prepared and their structures were confirmed by spectral methods (NMR and MS). Two compounds (Di-8 and Di-9) containing salicyl group in structure showed promising antithrombotic activity in screening experiment. Conclusion: The group of the proper active moiety in structure could improve the antithrombotic activity of diosgenin.