Preparation and evaluation of puerarin self-microemulsifying drug delivery system / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1512-1516, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-855553
ABSTRACT
Objective:
To study the formulation of puerarin (PUE) self-microemulsifying drug delivery system (SMEDDS).Methods:
The optimum formulation of PUE SMEDDS was screened by test of solubility, compatibility of oil and surfactant, and pseudo-ternary phase diagram, and the prescription of PUE SMEDDS was optimized by particle size, self-microemulsifying time, and drug loading; The physicochemical characteristics and stability were also determined.Results:
The optimum SMEDDS composed of Miglyol 812N (19.0%), oleic acid (19.0%), polysorbate 80 (19.0%), EL-35 (19.0%), 1, 2-propanediol (19.0%), and puerarin (5.0%). The particle size was (17.28 ± 0.24) nm, and self- microemulsifying time was less than 120 s; The appearance, content of PUE, particle size, and self-microemulsifying time had no obvious changes under room temperature storage for six months.Conclusion:
The acquired PUE SMEDDS is stable with small particle size, which meets the needs of good SMEDDS formulation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS