Optimization of synthetic process of PEGylated puerarin by orthogonal test with multi-index / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1528-1531, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-855556
ABSTRACT
Objective:
To optimize the synthesis of PEGylated puerarin (PEG-PUE) by orthogonal test with multi-index evaluation.Methods:
The research has focused on the optimized interacting factors of the synthetic process of PEG-PUE by HPLC, such as ratio of PEG and PUE, catalyst DMAP dosage, and reaction time, using the purity, drug loading, and yield of PEG-PUE as evaluation indexes.Results:
The optimum synthesis conditions of PEG-PUE were as follows, PEG-EDC-PUE-DMAP (1 1.2 1.2 0.3) and reaction time 12 h.Conclusion:
The optimum synthesis condition of PEG-PUE is reasonable, as well as feasible.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2011
Type:
Article
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