Transdermal permeation in vitro of Xiaoyan Zhentong Cataplasm / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 881-885, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-855600
ABSTRACT
Objective:
To study the transdermal penetration absorption of Salviae Miltiorrhizae Radix et Rhizoma, the monarch drug in Xiaoyan Zhentong Cataplasm and to optimize the transdermal penetration enhancers of Xiaoyan Zhentong Cataplasm.Methods:
The Franz diffusion cell was used to study the in vitro permeation behavior, and salvianolic acid B and Tanshinone IIA were chosen as indexes. Samples with different penetration enhancers were assayed by HPLC method to determine the cumulative permeation quantity and permeation rate of salvianolic acid B and Tanshinone IIA.Results:
When azone - propylene glycol (11), the permeation rates of salvianolic acid B and Tanshinone IIA through rat skin in vitro were 3.62 and 1.35 μg/(cm2·;h), respectively, and the 24 h permeated amounts were 88.72 and 16.12 μg/cm2, respectively. Compared with the Xiaoyan Zhentong Cataplasm without penetration enhancers, the permeation rates increased by 6 and 10 times, respectively.Conclusion:
The combination of Azone - propylene glycol (11) is an effective penetration enhancer both to water-soluble salvianolic acid B and liposoluble Tanshinone IIA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2011
Type:
Article
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