Enhancing effect of Borneolum Syntheticum and Acori Talarinowii Rhizoma on penetrating blood-brain barrier of hydroxysafflor yellow A / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 734-737, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-855631
ABSTRACT
Objective:
To investigate the enhancing effect of Borneolum Syntheticum and Acori Talarinowii Rhizoma on penetrating blood-brain barrier (BBB) of hydroxysafflor yellow A (HSYA) in rat.Methods:
The concentration of HSYA in rat plasma and brain was determinated after ig administration of 20.00 mg/kg of HSYA to rats with or without Borneolum Syntheticum and Acori Talarinowii Rhizoma. And then, the character of penetrating BBB through the result of the AUCbrain/AUCbloodwas evaluated.Results:
The AUC 0-8h, were (77 228.76±2 873.19), (81 949.04±2 283.11), and (28 479.63±2 431.71) ng·mL-1·min for blood and (55 925.0± 2 434.28), (82 768.53 ±3 277.00), and (70 914.29 ±2 900.71) ng·mL-1·min for brain of the control group, Borneolum Syntheticum group, and Acori Talarinowii Rhizoma group. The AUCbrain/AUCblood, were 0.72, 1.01, and 2.49, respectively.Conclusion:
Borneolum Syntheticum and Acori Talarinowii Rhizoma do enhance the penetrating BBB of HSYA (P<0.05). Further more, Acori Talarinowii Rhizoma could affect the distribution of HSYA in rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2011
Type:
Article
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