Preparation of β-elemene-polybutylcyanoacrylate nanoparticles / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 474-477, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-855651
ABSTRACT
Objective:
Optimizing the formula and preparation of β-elemene- polybutylcyanoacrylate nanoparticles (β-ELE-PBCA-NP).Methods:
With polybutylcyanoacrylate (PBCA) as the drug-loaded material, β-ELE-PBCA-NP was prepared by interfacial polycondensation. The preparation conditions were optimized by single factor design and the formula was optimized by orthogonal design with entrapment efficiency (EE) as index. EE of β-ELE-PBCA-NP was determinated by RP-HPLC.Results:
Under the optimal conditions, the prepared NPs were round and regular in shape without adhesions with average particle size of 254 nm and EE of 90.17%.Conclusion:
The optimized technology in this experiment is stable and feasible.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2011
Type:
Article
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