Effect of silkworm chrysalis oil on apoprotein and lipid-metabolizedenzyme level in hyperlipidemia rats / 中草药

ABSTRACT

Objective: To investigate the regulation of the silkworm chrysalis oil on the plasma lipid in hyperlipidemia rats and its mechanism. Methods: The rat model of hyperlipidemia was built by high fat diet and then ig administration of silkworm chrysalis oil for six weeks to observe TQ TC, HDL-C, LDL-C, ApoAI, ApoB, LCAT, LPL, and HL levels in the serum of rat every two weeks, then killed the rats in the sixth week, weighed the liver, and detected the LPL and HL levels in the liver. Results: Compared to the indexes of model group, the blood lipids (TG and TC), lipoprotein (HDL-C and LDL-C), apoprotein (ApoAI and ApoB), LCAT, LPL, and HL levels of the rats in every group treated with silkworm oil were significantly different (P<0.05) in a dose-dependent manner, and the change of the relative enzyme level was earlier than that of the blood lipid and lipoprotein level. Conclusion: The silkworm chrysalis oil could regulate the plasma lipid and lipoprotein levels in the serum of rats by activating apoprotein and correlating lipid-metabolizedenzyme, thereby to treat the hyperlipidemia.