Bioassay-guided separation and acute toxicity evaluation of antitumor ingredient in Bufonis Venenum / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 307-311, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-855681
ABSTRACT
Objective:
To obtain antitumor active compounds with lower toxicity from main ingredients of Chinese materia medica Bufonis Venenum.Methods:
Taking inhibition of in vitro tumor cells as active indexes, a bioassay-guided separation and toxicity evaluation in mice of ingredients in Bufonis Venenum were applied.Results:
Bufotalin was seperated from Bufonis Venenum with significant inhibition and lower acute toxicity by active tracking method. The inhibitory effect on the proliferation of A549 was better, LD50 of bufotalin by iv administration to mice is about four times of bufalin, and bufotalin is stable. Conclusion Integrated the activity, toxicity, and stability factors of the compounds, bufotalin from Bufonis Venenum will deserve further research than any other similar compounds in potential antitumor activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2011
Type:
Article
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