In vitro transdermal permeability of Xiaoer Fuxie Navel Plaster investigated on different animals' skin / 中草药

ABSTRACT

Objective: To investigate the effect of different animal's skin and different concentration of one penetration enhancer on the transdermal permeability of Xiaoer Fuxie Navel Plaster. Methods: Using Franz diffusion cell and HPLC, and taking psoralen and isopsoralen as index components, the differences in transdermal permeability of abdominal skin of rats and rabbits, back skin of mice, and ear skin of pigs, and the effects of different concentration of 1%, 3%, and 5% of Azone on transdermal permeability of Xiaoer Fuxie Navel Plaster were compared and studied. Results: Abdominal skin of rats profited to the transdermal penetration of psoralen and isopsoralen, the 24 h-accumulated permeattion of both psoralen and isopsoralen reached the maximum and the penetration rate was the highest and the effect of penetration enhancers was the strongest at the concentration of 1% Azone. Conclusion: The transdermal effect of Xiaoer Fuxie Navel Plaster could be best when choosing 1% Azone as the penetration enhancer and abdominal skin of rats as screening model of penetration enhancer.