Influencing factors of early neurological deterioration after intravenous thrombolysis in acute cerebral infarction / 中国脑血管病杂志

ABSTRACT

Objective: To investigate influencing factors of early neurological deterioration (END) in acute cerebral infarction patients after intravenous thrombolysis. Methods: From March to August in 2018,a total of 139 consecutive acute cerebral infarction patients receiving intravenous thrombolysis within 4.5 h after onset in Department of Neurology of Xuanwu Hospital, Capital Medical University were recruited These patients included 116 males and 23 females. According to the presence of END after intravenous thrombolysis, the patients were divided into the END group (n =25) and the non-END group (n = 114). Baseline and clinical data were collected and compared between the two groups,including age,sex,past medical history (hypertension,diabetes,coronary heart disease,congenital heart disease,atrial fibrillation,hyperlipidemia, ischemic stroke [cerebral infarction, transient ischemic attack]), smoking, the National Institute of Health Stroke Scale (NIHSS), low-density lipoprotein cholesterol, blood glucose, blood pressure, proportion of anterior circulation infarction and the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. Multivariate logistic regression analysis was performed for END incidence of these patients with the parameters of P 0. 05). (4) The large-artery atherosclerosis rate of the END group was significantly higher than that of the non-END group (76. 0% [19/25]vs. 45. 6% [52/114],χ2 =7. 576, P0.05). Conclusion Large-artery atherosclerosis in TOAST classification can increase the risk of END after intravenous thrombolysis in patients with acute cerebral infarction.