Application of diffusion tensor imaging of white matter fiber bundles in rhesus models of cerebral infarction / 中国脑血管病杂志

ABSTRACT

Objective To investigate the diagnostic value of MR diffusion tensor imaging (DTI) and diffusion tensor fiber bundle imaging (DTT) in white matter injury of cerebral infarction in different periods, and to observe the damage of white matter fiber bundles. Methods Four adult male rhesus monkeys, aging 8. 0 ± 1. 5 years old and weighted 9. 6 ± 1. 2 kg were experimented. Middle cerebral artery (Ml segment) embolization-reperfusion model was prepared by rhesus monkey autologous thrombosis and recanalization with recombinant tissue plasminogen activator 2. 5 h after embolization. Routine magnetic resonance imaging (MRI), diffusion weighted imaging (DWI) and DTI were performed at 4 h, 7 d and 30 d after surgery, respectively. The anisotropic coefficient (FA) values and changes of the white matter fiber bundles in corresponding parts of cerebral white matter between the infarcted side and the healthy side were compared. Results FA and the number of fiber bundles in the infarct side showed a trend of decrease on day 7 and increase on day 30 after ischemia, and the difference was statistically significant (At 4 h, 7 d and 30 d after cerebral ischemia, FA was 0. 301 ± 0. 045, 0. 200 ± 0. 050 and 0. 305 ± 0. 026, respectively The number of fiber bundles was 43. 0 ± 1. 6, 22. 8 ±11.0 and 31.3 ± 6. 4, respectively. F values were 8. 223 and 7. 861, respectively; all P 0. 05). Conclusion DTI and DTT can better evaluate the degree of white matter fiber bundle injury in cerebral infarction at different stages, which is of great value in guiding clinical diagnosis and predicting prognosis.