Clinical features in chronic insomnia comorbidity with silent cerebral small vessel disease / 中国脑血管病杂志

ABSTRACT

Objective To investigate the clinical features of chronic insomnia patients with cerebral small vessel disease (CSVD). Methods This cross-sectional study consecutively enrolled one hundred out-patient and in-patient patients meeting the diagnostic criteria of chronic insomnia at the department of psychiatry and neurology in tlie third affiliated hospital, Sun Vet-sen University from January 2018 to April 2019.Tlie patients (52-75 years) received magnetic resonance ( MR) .polysomnography ( PSG) , Montreal Cognitive Assessment (MoCA) in two weeks after enrollment. The subjective symptoms were evaluated by visual analogue scale ( VAS). Patients with comorbid CSVD were in the experimental group (28cases) .while those with simple insomnia were in the control group (72 cases). 11 ie differences of symptoms,I∗SC parameters and cognitive function between the two groups were compared. Results In the experimental group, only dizziness of subjective symptoms was higher than that in the control group (7. 0 [4. 5,8. 0] vs. 4. 0 [2. 0, 6. 0] ). The experimental group also had higher PSC monitored awakening time after sleep (105. 8 [66. 7, 141.3] min to 70. I [35.4,116.8] min) .arousal index ([29 ±8] limes/h vs. [21 ±6] times/h) , ratio of nonrapid eye movement sleep 1 phase ([15 ±4] % vs. [ 10 ±3] %) than the control group,but lower sleep efficiency ([67 ± 18] % vs. [75 ± 15] % ). The total MoCA score (19.0 [15.0,24.0] to 23.5 [ 17.0,26. 5]) .visuospatial score (2.0 [ 1.0,3.0] vs. 2. 5 [ 1.5,3.0]) .executive function score (2.0 [ I. 0,3.0] vs. 2.5 [2.0,3.0]) and short-term memory score (2. 5 [ I. 0,4.0] vs. 3. 0 [2.0,4. 0]) in the study group were significantly lower than that in the control group (/' <0. 05). Conclusion Chronic insomnia with CSVD is common with concealing subjective symptoms,and it needs to be identified from the aspects of cognitive assessment and sleep monitoring.