Advance in predisposing factors for moyamoya disease / 中国脑血管病杂志

ABSTRACT

Moyamoya disease ( MMD) is a progressive cerebrovascular disease with characteristics of ethnic susceptibility and familial aggregation. The pathological changes of slenosed vessels in MMD includc intima thickening,tunica media thinning,irregular undulation of the internal elastic laminae and lymphocytic infiltration The etiology and pathogenesis arc not completely clarified. It is presently thought that this disease is related to endothelial cells,smooth muscle cells,abnormal metabolism of extracellular matrix and inflammatory responses. This review will discuss,from genetic.cellular environmental and immunological perspectives,the specific roles of several genes in the development of MMD, including endothelial cell susceptibility gene ring finger protein 213,smooth muscle ccll susceptibility genes,extracellular matrix genes,angiogenesis factors and immune-related genes.