Research advancement of wnt signaling pathway regulating vascular smooth muscle cells in cerebrovascular disease / 中国脑血管病杂志

ABSTRACT

In modern society,the spectrum of human diseases has changed significandy. Cerebrovascular diseases have become a huge threat to human health. Vascular smooth muscle cells,which constitute the main components of the cerebrovascular wall, play a key role in cerebrovascular diseases. Understanding the physiological metabolism of vascular smooth muscle cells is helpful to the research of cerebrovascular diseases. In recent years, researchers found that Wnt protein and Wnt signaling pathway were widely involved in cerebrovascular diseases. Wnt signaling pathway plays an important role in the proliferation,migration and apoptosis of smooth muscle cells. This review, based on Wnt signaling pathway, will explore the relationship between vascular smooth muscle cells and cerebrovascular lesions.