The relationship between intracranial arterial stenosis and plasma lipid and uric acid levels in elderly patients with hypertension / 中国脑血管病杂志

ABSTRACT

Objective: To explore the relationship between asymptomatic intracranial arterial stenosis and plasma lipid and uric acid levels in elderly patients with hypertension. Methods: A total of 164 elderly patients with hypertension were selected during the physical examination. Transcranial Doppler (TCD) sonography found that 56 patients had intracranial arterial stenosis (stenotic group) and 108 patients without stenosis (nonstenotic group). In addition, 36 age-and sex-matched healthy controls were selected as control group. Plasma lipid and uric acid levels were detected by automatic biochemistry analyzer in the 3 groups. Results: The levels of plasma total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and uric acid in the stenotic group were 6.0 ± 1.1 mmol/L, 1.7 ± 0.9 mmol/L, 3.8 ± 0.9 mmol/L, and 437 ± 115 μmol/L, respectively; they were 5.4 ± 1.1 mmol/L, 1.7 ± 1.0 mmol/L, 3.3 ± 0.9 mmol/, and 372 ± 78 μmol/L, respectively in the nonstenstic group; and they were 4.9 ± 0.5 mmol/L, 1.1 ± 0.5 mmol/L, 1.42 ± 0.26 mmol/L, and 324 ± 56 μmol/L, respectively in the control group. There were significant differences between the stenotic and nonstenotic groups with the control group (P<0.001); and there were significant differences between the stenotic group and the nonstenotic group either in the levels of plasma TC, LDL-C, and uric acid (P=0.002, P=0.002, P= 0.000). Conclusion: The increase of the levels of plasma TG, LDL-C and uric acid are the risk factors of intracranial arterial stenosis in elderly patients with hypertension.