The Effects of Moxifloxacin in Endotoxin-induced Acute Lung Injury / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 1-8, 2009.
Article
in Korean
| WPRIM
| ID: wpr-85645
ABSTRACT
BACKGROUND:
The pathophysiology of acute respiratory distress syndrome with sepsis is acute lung injury (ALI) that's' caused by endotoxin (LPS). We evaluate effects of moxifloxacin on LPS-induced ALI in a rat model. MATERIAL ANDMETHOD:
The rats were divided into 3 groups as the control group (C), the LPS insult group (L), and the LPS+moxifloxacin treated group (L-M). ALI was induced by endotracheal instillation of E.coli LPS, then moxifloxacin was given in 30 minutes. Five hours later, we checked the lung weight/body weight ratio(the L/BW ratio), the protein & neutrophils in the bronchoalveolar lavage fluid (BALF), the myeloperoxidase (MPO) activity & the malondialdehyde (MDA) content, the expressions of cytosolic and secretory phospholipase A2 (c, sPLA2), and the morphology of the lung with using a light microscope.RESULT:
The L/BW ratio, the protein content and the neutrophil count in the BALF, and the MPO activity and the MDA content in lung were significantly increased in group L compared to group C, and these factors were markedly decreased in group L-M compare to group L. The cPLA2 expression and the sPLA2 expression were increased in group L and the cPLA2 expression was decreased in group L-M. Yet the sPLA2 expression was not changed in group L-M. Morphologically, many inflammatory findings were observed in group L, but not in group L-M.CONCLUSION:
Many of the inflammatory changes of ALI that were caused by LPS insult were ameliorated by moxifloxacin treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quinolines
/
Respiratory Distress Syndrome
/
Aza Compounds
/
Bronchoalveolar Lavage Fluid
/
Peroxidase
/
Sepsis
/
Cytosol
/
Phospholipases A2, Secretory
/
Acute Lung Injury
/
Light
Type of study:
Prognostic study
Limits:
Animals
Language:
Korean
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
2009
Type:
Article
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