Serum transferrin as a liver fibrosis biomarker in patients with chronic hepatitis B
Clinical and Molecular Hepatology
;
: 347-354, 2014.
Article
in English
| WPRIM
| ID: wpr-85685
ABSTRACT
BACKGROUND/AIMS:
Transferrin and alpha-1 antitrypsin are reportedly associated with liver fibrosis. We evaluated the usefulness of serum transferrin and alpha-1 antitrypsin as new liver fibrosis markers in patients with chronic hepatitis B.METHODS:
The study included 293 patients with chronic hepatitis B who underwent a liver biopsy between October 2005 and June 2009, and who had no history of hepatocellular carcinoma. Serum markers and liver fibrosis stages were compared.RESULTS:
Univariate analysis revealed that age (P<0.001), serum platelet count (P<0.001), and serum alkaline phosphatase level (P=0.003) differed significantly between the patients with and without liver cirrhosis. Serum transferrin levels were significantly lower in advanced fibrosis than in mild fibrosis in both univariate analysis (P=0.002) and multivariate analysis (P=0.009). In addition, the serum transferrin level was significantly lower in cirrhotic patients than in noncirrhotic patients (P=0.020). However, the serum level of alpha-1 antitrypsin was not significantly associated with liver cirrhosis in patients with chronic hepatitis B.CONCLUSIONS:
Serum transferrin could be promising serum marker for predicting advanced liver fibrosis in patients with chronic hepatitis B.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biomarkers
/
Alpha 1-Antitrypsin
/
Multivariate Analysis
/
Retrospective Studies
/
ROC Curve
/
Area Under Curve
/
Hepatitis B, Chronic
/
Transferrins
/
Liver Cirrhosis
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clinical and Molecular Hepatology
Year:
2014
Type:
Article
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