RESEARCH PROGRESS OF PATHOGENESIS MECHANISM OF SPINAL DEFORMITY IN NEUROFIBROMATOSIS TYPE 1 / 中国修复重建外科杂志
Chinese Journal of Reparative and Reconstructive Surgery
;
(12): 1174-1178, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-856908
ABSTRACT
OBJECTIVE:
To review the research progress of pathogenesis mechanism of spinal deformity in neurofibromatosis type 1 (NF1).METHODS:
Recent literature concerning the pathogenesis mechanism of spinal deformity in NF1 was extensively reviewed, and current developments of the correction of spinal deformity and NF1 and the pathogenesis mechanism were summarized.RESULTS:
The pathogenesis mechanism of spinal deformity in NF1 is not yet clearly known. Current theories include erosion and stress of neurofibromas, melatonin-related decreased contractility of paraspinal muscles, osteopenia and osteoporosis, sexual precocity and mesoderm dysplasia.CONCLUSIONS:
The clinical manifestations of NF1 may cause the spinal deformities in patients with NF1. The research of pathogenesis mechanism of spinal deformity in NF1 will be conducive to further understanding, diagnosis and treatment of NF1-related spinal deformity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
Chinese Journal of Reparative and Reconstructive Surgery
Year:
2016
Type:
Article
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