Advances in role of inflammasome in fibrotic diseases / 中国药理学通报

ABSTRACT

The inflammasome—a molecular complex of proteins whose activation and subsequent secretion of inflammatory cytokines are essential for innate immune defense, playing an significant role in adaptive immune responses. Fibrosis is the final stage of the development of chronic inflammation, which is the result of excessive deposition of extracellular matrix, leading to tissue structure damage and organ dysfunction. This paper reviews the role of inflammasome in fibrotic diseases in order to promote the research and development of inflammasome mechanisms and drugs.