Research progress on effect and mechanism of cannabidiol in drug dependence / 中国药理学通报

ABSTRACT

Drug abuse is a serious public health and social problem in the world today. Due to its strong mental dependence, high relapse rate and high neurotoxicity, it has a serious negative impact on the family and society. However, the effective treatment of drug dependence is siili an obstacle in the medical and health care. Cannabidiol is a non-toxic component extracted from plant marijuana, which has potential value in treatment of a variety of nervous system diseases (such as Parkinson'sdisease, epilepsy, Alzheimer's disease, etc.)and has attracted wide attention. Recent studies have shown that Cannabidiol has a good intervention effect on psycho-dependence induced by methamphetamine, morphine, cocaine, alcohol and other drugs, but the specific mechanism is still unclear. This paper reviews the role of marijuana in the intervention of drug dependence and its related mechanisms, in order to further study the potential value and related mechanisms of marijuana in treatment of drug dependence, aiming to further study the potential value and related mechanisms of cannabidiol in treatment of drug dependence, and to provide important references for discovering new mechanism targets for the prevention and treatment of drug dependence.