Molecular mechanism of cisplatin-induced nephrotoxicity and intervention of traditional Chinese medicine / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 13-18, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-857036
ABSTRACT
Cisplatin (DDP) is one of the most commonly used medicines in combination chemotherapy; however, its clinical upplicaiion is greatly limited by nephrotoxicity. In the present paper, the molccular mechanisms including cytotoxicity, oxidative stress, inflammation and apoptosis signaling pathways on DDP-induccd nephrotoxicity were discussed, and the relationship between DDP-induced nephrotoxicity and transporters and raiRNAs was also analyzed. In addilion, recent advances on tra-ditional Chinese medicines (TCMs) for the preventicn and treatment of DDP-induced nephrotoxicity were reviewed, aiming to provide useful information for the research and development of innovative drugs in the treatment of DDP-induced nephrotoxicity. Key words Cisplatin; nephrotoxicity; cytotoxicity; oxidative stress; inflammation; apoplosis; traditional Chinese medicine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2020
Type:
Article
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