Progress in research on anti-tumor mechanism of NK cell and its related immunotherapy / 中国药理学通报

ABSTRACT

A s an important member of the body' s innate immunity and the pioneer of anti-tumor immunity, natural killer (NK) cells play a vital role in tumor immunity. Therefore, NK cell-based anti-tumor immunotherapy has increasingly become an emerging field of scientific research. NK cells have a cytotoxic effect on a variety of tumor types, and early clinical means to enhance T cell toxicity can also activate NK cells to exert a dual anti-tumor effect. This review summarizes the role of NK cells in anti-tumor immunity and its related mechanisms, and summarizes monoclonal antibodies .cytokine therapy and adoptive therapy targeting NK cells. In addition, this review clarifies the status and trends of NK cell immunotherapy and provides ideas and lessons for clinical research.