Progress in evaluation methods and mechanisms of opioid receptor-mediated side effects / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 1501-1504, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-857092
ABSTRACT
K opioid receptor agonists produce potent antinociception without morphine-like side effects. However, selective K opioid receptor agonists exhibit severe dysphoria, limiting their clinical use. Developing new K agonists with less CNS side effects appears to offer some advantages over u, agonist for the treatment of pain. In this review, we summarize the representative analgesics targeting K opioid receptors in the clinic and introducethe latest progress of methodology and underlying mechanism of K receptor-mediated dysphoria.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2019
Type:
Article
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