Research progress on interactions among tissue renin-angiotensin system, vitamin D receptor and Wnt/β-catenin in chronic diseases / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 1338-1341, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-857114
ABSTRACT
This review discusses the mutual regulative effects of Wnt/β-catenin signaling pathway, tissue renin-angiotensin system (RAS) and vitamin D receptor (VDR) pathway in chronic non-infectious diseases (abbr. chronic diseases). The interaction between RAS and Wnt/β-catenin might induce the occurrence of multiple chronic diseases. The activation of VDR inhibits Wnt signaling transduction through blocking the action of β-catenin on down-stream genes via various pathways. Moreover, the agonists on VDR suppress the biological actions of RAS in whole circulation and local tissues. Thus, Wnt/β-catenin signaling pathway, RAS and VDR synergistically exert vital biological modulations on the pathophysiological process of chronic diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2019
Type:
Article
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