Genetic Variants in the Wnt Signaling Pathway Are Not Associated with Survival Outcome of Non-Small Cell Lung Cancer in a Korean Population
Journal of Korean Medical Science
;
: 463-466, 2016.
Article
in English
| WPRIM
| ID: wpr-85712
ABSTRACT
Recently, genetic variants in the WNT signaling pathway have been reported to affect the survival outcome of Caucasian patients with early stage non-small cell lung cancer (NSCLC). We therefore attempted to determine whether these same WNT signaling pathway gene variants had similar impacts on the survival outcome of NSCLC patients in a Korean population. A total of 761 patients with stages I-IIIA NSCLC were enrolled in this study. Eight variants of WNT pathway genes were genotyped and their association with overall survival and disease-free survival were analyzed. None of the eight variants were significantly associated with overall survival or disease-free survival. There were no differences in survival outcome after stratifying the subjects according to age, gender, smoking status, and histological type. These results suggest that genetic variants in the WNT signaling pathway may not affect the survival outcome of NSCLC in a Korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Smoking
/
Demography
/
Carcinoma, Non-Small-Cell Lung
/
Disease-Free Survival
/
Polymorphism, Single Nucleotide
/
Asian People
/
Kaplan-Meier Estimate
/
Republic of Korea
/
Wnt Signaling Pathway
/
Genotype
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2016
Type:
Article
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