Role and mechanism of incrna in chronic liver diseases / 中国药理学通报

ABSTRACT

Long noncoding RNA( IncRNA) is a group of RNA transcripts with a length of >200 nt and does not function as an encoded protein. It functions at epigenetic, transcriptional, and post-transcriptional levels. IncRNA, involved in a variety of life processes in liver cells, has gradually become a hot topic in chronic liver diseases, including chronic hepatitis, non-alcoholic fatty liver, liver fibrosis, and liver cancer, etc, especially in liver cancer. This article elaborates the close relationship be tween IncRNA and chronic liver disease based on the classification of different chronic liver diseases, summarizes the regulatory mechanism to predict new targets of IncRNA, and provides research basis and new ideas for the study and prevention of chronic liver disease.