Roles of mitochondria-associated endoplasmic reticulum membranes in ischemic stroke / 中国药理学通报

ABSTRACT

Mitochondria-associated endoplasmic reticulum membranes (MAM) provide an excellent scaffold for crosstalk between ER and mitochondria, which play an important role in Ca2+ homeostasis, oxidative stress, inflammation, mitochondrial morphological and functional regulation, lipid metabolism, apop-tosis, autophagy and other processes. With the in-depth research, the function of MAM and the pathophysiological mechanisms of ischemic stroke overlap highly. On the other hand, a variety of drugs or compounds protect against ischemic stroke by affecting MAM-related proteins. In this review, we summarize the critical role of MAM in ischemic stroke and the potential of MAM as one drug target for treating ischemic stroke.