Advance in mechanism study of inflammation in post-ischemic stroke and opportunity of new drug development / 中国药理学通报

ABSTRACT

Inflammation mediated by the damage-associated molecular patterns (DAMPs) moleculesdominates the pathological process of ischemic stroke in the middle and late stages. In this process, the activation of immune cells and subsequent production of various inflammatory cytokines, chemokines and other cytotoxic mediators are the key factors that trigger inflammation injuries after ischemia. Meanwhile, this mechanism also induces the formation of immune cells with anti-inflammatory activities and tissue repair properties, boosting the regeneration of damaged never system. DAMPs-TLR-NF-κB inflammatory activation chain as the main axis of new anti-stroke drug approaches has become a direction to explore the novel treatments of stroke, which also provides a rational basis for anti-inflammatory therapy in clinical practice for stroke patients. In this paper, we highlighted the current status on the mechanism study with focus on the activation chain of macrophage and microglia involved in DAMPs-TLR-NF-κB in inflammation after stroke and discussed the future development in searching the potential new treatments and therapeutic agents which could be applied in clinics.