Neuroprotective effect of ticagrelor against global cerebral ischemia/reperfusion injury in rats / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 413-418, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-857358
ABSTRACT
Aim:
To research the neuroprotective effect of ticagrelor against global cerebral ischemia/reperfusion injury in rats.Methods:
Fifty adult male Wistar rats were randomly divided into five groups; sham-operation, vehicle, ticagrelor of 3 doses (37.5, 75, 150 mg · kg-1, ig). The global cerebral ischemia was established with four-vessel occlusion. Apoplexy index and neurological symptoms were detected after reperfusion injury 2 h, 24 h, 48 h. HE staining and Nissl staining were applied to assess the neuronal injury after global cerebral ischemia/reperfusion injury in CA1 region of hippocampus. Platelet aggregation induced by ADP in rats was measured with turbidimetric method. Four items of coagulation were detected by automatic coagulation analyzer.Results:
Compared with vehicle, the low, medium and high doses of ticagrelor reduced the apoplexy index at 24h (P <0. 05), 48 h(P < 0. 01), and significantly reduced the neurological symptom at 48 h (P < 0. 01), and could significantly reduce platelet aggregation of rats (P < 0. 01), the number of neurons in CA1 region of hippocampus was larger (P < 0. 01), and it also significantly protected the neurons in both number and morphology.Conclusions:
The ticagrelor possesses neuroprotective effect against global cerebral ischemia/reperfusion injury in rats, and it may be as a drug of neuroprotective agent in further study.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2019
Type:
Article
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