Comparative observation on drinking behavior of FH/Wjd rats and SD rats with different liquors / 中国药理学通报

ABSTRACT

Aim: To observe the preferences and drinking behavior characteristics of congenital alcoholism in (FH/Wjd) rats and SD rats. Methods: Both FH/Wjd rats and SD rats were fed with free access to two bottles (liquor A, liquor B, 53% alcohol and water). The intake of liquor and water and their preference, the difference in day and night intake of each liquor, and the variation of ethanol and water intake and the preference after depriving were compared between FH/Wjd rats and SD rats. Results: The rate of preference for liquor A was significantly higher than liquor B and 53% alcohol in FH/Wjd rats; however, the rate of preference for liquor B was significantly higher than that for liquor A and 53% alcohol, and the liquor A was higher than 53% alcohol in SD rats. It was found that the longer the drinking time, the more of alcohol consumption and the higher preference for each liquor in both FH/Wjd rats and SD rats. In addition, the drinking behavior of FH/Wjd rats and SD rats for each liquor showed a significant difference between day and night, with robust ethanol deprivation effect. Conclusions: SD rats can be forced to drink for short time, and prefer liquor B. However, FH/Wjd rats prefer liquor A. Both SD rats and FH/Wjd rats have the characteristics that the longer the drinking time, the more of alcohol consumption and the higher of preference. Obvious difference exists between day and night; the more alcohol consumption and higher rate of preference after deprivation appear in both SD rats and FH/Wjd rats.