Inflammatory cytokines and Alzheimers disease / 中国药理学通报

ABSTRACT

Inflammatory response clearly occured in pathologically vulnerable regions of the Alzheimers disease (AD) brain. Many proinflammatory mediators, such as IL-1, IL-6, TNF-α and TGF-β, were significantly up-regulated in the pathophysiological process of AD. In addition to their traditional actions as proinflammatory molecules, AD-specific interactions of the cytokines and amyloid β(Aβ) may be pathophysiologically relevant, and there was a reciprocal relationship within the cytokines inducing and being induced by Aβ.