Progresses in pharmacological action of cerebral σ receptor / 中国药理学通报

ABSTRACT

σ receptors are particularly abundant in the CNS. σ receptors have been shown to exhibit such a wide variety of actions as modulating glutaminergic, dopaminergic and cholinergic neurotransmission. They also play an important role in maintaining cell growth and proliferation, learning and memory. Recent evidence suggests the possible involvement of σ receptors in the pathogenesis of schizophrenia. More researches are expected to supply new targets for treatment and diagnosis.