Research progress of protein kinase C-zeta / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 13-16, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-857413
ABSTRACT
Protein Kinase C-zeta (PKC-ζ) is a new member of protein kinase C family and has some specific characteristics as comparing with the classical PKC. It lacks the C2 domain making its kinase activity Ca2+ -independent, and it possesses only one zinc-finger region in its regulatory domain. Therefore, PKC-ζ does not bind Ca2+ and can not be activated by diacylglycerol or phorbol esters. In addition, many researches showed that PKC-ζ could induce differentiation, mediate insulin-stimulation protein synthesis, activate immunity of human neutrophils, inhibit proliferation of cancer cells and regulate the function of actin cytoskeleton. What is more, PKC-ζ plays an important role in signal transduction of cells, such as mediating MAPK and NF-κB activation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2002
Type:
Article
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