Effect of chicken collagen type II on collagen-induced arthritis in mice / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 76-79, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-857431
ABSTRACT
AIM:
To investigate the effect of chicken collagen type II (C II) on collagen-induced arthritis (CIA) mice.METHODS:
The model of mice CIA was prepared and the change of the mean of arthritis scores was observed. Meanwhile, ConA and LPS-induced, splenocytes proliferation and the production of interleukin (IL)-1 and IL-2 were measured.RESULT:
CII [5, 10, 20 μg·kg-1ig × 7 d] significantly decreased the mean of arthritis scores, inhibited the increased ConA-induced splenocytes proliferation as well as the elevated production of IL-1 and IL- 2. Meanwhile, the pathological examination showed that articulus cartilage degeneration with synovial hyperplasia and inflammatory cells infiltration in CIA mice was suppressed by ig C II .CONCLUSION:
C II has therapeutical effect on mice CIA which may be related to its immunoregulative function.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2002
Type:
Article
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