Progressing growth of tumor cell and synthesis of Bip/GRP78 / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 79-83, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-857432
ABSTRACT
AIM:
To explore the relationship between tumor progressing growth and synthesis of Bip/GRP78 in vitro.METHOD:
Using tumor cell culture, ion exchange chromatography, SDS-PAGE, specific enzymatic, chemical catalysis, mass spectra and so on, the synthesis of Bip/GRP78 of cells growth in exponential, confluent and post-confluent phases was examined,and compared to normal breast epithelial cells.RESULTS:
During the progressing growth, tumor cells' synthesis of Bip/GRP78 exhibited growth situation, cell density and malignant degree-dependent.CONCLUSIONS:
During the progressing growth, tumor cells can maintain its homeostasis by synthesizing Bip/GRP78. This synthesis is intensely growth situation. Cell density and malignant degree-dependent. By this synthesis, tumor cell establishs its defensive system. Because increasing investigate results have shown that Bip/GRP78 can decrease the sensitivity of tumor cell to be killed by cytotoxic T lymphocytes, increase its tumorigencity and prevent its apoptosis. So aiming at destruction of the synthesis of Bip/GRP78 may point to a new approaches to the therapy of cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2002
Type:
Article
Similar
MEDLINE
...
LILACS
LIS